In my experience, Choleast has regularly lowered total cholesterol by 30 points or more in less than eight weeks. I generally have the patient take two pills, three times a day along with other beneficial lifestyle components. Choleast (red yeast rice powder) is derived from Monascus purpureus WENT, an organism grown on rice. After centuries of use in Traditional Chinese Medicine, it was discovered that red yeast rice is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the rate-limiting enzyme in cholesterol synthesis. This means that it helps your body not make additional cholesterol. The fatty acids, phytosterols, isoflavones, and proteins in Choleast help maintain a healthful balance of cholesterol and related blood lipids in the body. Thorne Research's Choleast combines red yeast rice powder with coenzyme Q10.